Components of Pneumococcal Vaccine	Excipients Table Allergens Table Components Table
Indication Immunity in infants and children against S. pneumoniae Active immunization of infants and toddlers against invasive disease caused by S. pneumoniae due to capsular serotypes included in the vaccine (4, 6B, 9V, 14, 18C, 19F, and 23F). Prevention of invasive disease caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F Also for the prevention of otitis media caused by S. pneumoniae serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F Proprietary Name Pneumovax 23 Prevnar Prevnar 13 Manufacturer Merck Pfizer Pfizer Viability Inactivated Inactivated Inactivated Microorganism Streptococcus pneumoniae 23-valent serotype   Streptococcus pneumoniae 7-valent serotype Streptococcus pneumoniae 13-valent serotype Approved Ages ≥  50 years ≥ 2 years in select populations  6 weeks - 9 years  6 weeks - 5 years ≥  50 years Dose 0.5 mL 0.5 mL 0.5 mL Route Intramuscular or Subcutaneous Intramuscular Intramuscular Dose form Solution Suspension Suspension Appearance Clear, colorless solution Homogeneous, white suspension Homogeneous, white suspension Concentration (per 0.5 mL) Streptococcus pneumoniae types 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19F, 19A, 20, 22F, 23F, 33F (23 types), 25 mcg each Streptococcus pneumoniae serotypes 4, 9V, 14, 18C, 19F, and 23F, 2 mcg each Serotype 6B, 4 mcg Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 7F, 9V, 14, 18C, 19A, 19F, 23F saccharides, 2.2 mcg each 6B saccharides, 4.4 mcg Excipients None Diphtheria CRM197, 20 mcg Aluminum as aluminum phosphate, 0.125 mg CRM197 carrier protein, 34 mcg Polysorbate 80, 100 mcg Succinate buffer, 295 mcg Aluminum as Aluminum phosphate, 125 mcg Adjuvants Aluminum as aluminum phosphate, 0.125 mg Diphtheria CRM197, 20 mcg Aluminum phosphate, 0.125 mg Aluminum as Aluminum phosphate, 125 mcg Allergens None Dry natural rubber None Preservatives Phenol, 0.25% None None Media Bovine proteins and other macromolecular components Soy peptone broth Soy peptone broth Packaging Vials, 5-dose, 10 5-dose vials, 10 single-dose vial Vial, 1 dose (10 per package) Syringe, (10 per package) Routine storage 2 to 8° C (35-46° F) Do not freeze 2 to 8° C (35-46° F) Do not freeze 2 to 8° C (35-46° F) Do not freeze Package Insert date Oct 2011 July 2009 Jan 2012 updated Janury 2012
This page was last updated on January 24, 2012 © 2012 Institute for Vaccine Safety