Components of Smallpox Vaccine	Excipients Table Allergens Table Components Table
Indication Active immunity against vaccinia and smallpox Proprietary Name ACAM2000 Manufacturer Sanofi Pasteur Viability Live attenuated Microorganism Vaccinia virus. Note: This vaccine does not contain smallpox virus (variola) and cannot spread or cause smallpox. Approved Ages All age groups link to approval letter Dose 0.0025 mL administered using 15 jabs of a bifurcated needle dipped into the vaccine Route Percutaneous (scarification) Appearance Clear to slightly hazy, colorless to straw-colored Concentration 2.5 x 105 plaque-forming units  Excipients HEPES, 6-8 mM Human serum albumin, 2% Sodium chloride, 0.5 – 0.7% Mannitol, 5% Neomycin, trace amounts Polymyxin B, trace amounts  Adjuvant None Allergens Neomycin, trace amounts Polymyxin B, trace amounts Preservatives Phenol 0.25% Media African Green Monkey kidney (Vero) cells Packaging Vials, multiple-dose 3 mL clear glass vials containing lyophilized powder Diluent, in 3 mL clear glass vials containing 0.6 mL of diluent Routine Storage 2 to 8° C Shipped at 0° C or cooler Package Insert updated September 2009 updated January 2012
This page was last updated on January 23, 2012 © 2012 Institute for Vaccine Safety